We develop computational methods and software for Scientific research, including:

  • X-ray scattering
  • CryoEM image processing
  • Model reconstruction and refinement
  • Single particle tracking
  • Molecular dynamics simulations (mostly for data analysis)

Available programs:

  • SASTBX : open source program, initially for small angle x-ray scattering data analysis (started with Dr. P. Zwart at Berkeley National Lab)
  • SPaT : Statistics for single particle tracking, Matlab scripts to get statistics properties from tracks
  • OSobj : Object reconstruction from oversampling data using “molecular replacement” type algorithm
  • coreshell diffraction data analysis: Data analysis scripts for coreshell diffraction patterns.
  • Step-wise Orientation Determination: Step-wise Euler angles reconstruction for Cryo-EM image processing

Richard Feynman

“everything that is living can be understood in terms of the jiggling and wiggling of atoms”.

and now, we want to watch atoms jiggling and wiggling.

X-rays, electrons, fluorescence light, the advances of photon sciences, together with computational modeling, are making this happen.